Liproxstatin-1
Product Specifications
UNSPSC Description
Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Liproxstatin-1.html
Purity
99.90
Solubility
DMSO : ≥ 31 mg/mL
Smiles
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
Molecular Weight
340.85
References & Citations
[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12726/Liproxstatin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12726/Liproxstatin-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
950455-15-9
Available Sizes
Curated Selection
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