Liproxstatin-1
Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].
Product Specifications
CAS Number
[950455-15-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Liproxstatin-1.html
Purity
99.70
Solubility
DMSO : ≥ 31 mg/mL
Smiles
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
Molecular Formula
C19H21ClN4
Molecular Weight
340.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16 (12) :1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3 (3) :232-243
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6495245-01 0.2 mL
PKC iota, NT (Protein Kinase C iota Type, Atypical Protein Kinase C-lambda/iota, PRKC-lambda/iota, aPKC-lambda/iota, nPKC-iota, PRKCI, DXS1179E) (PE)
Ask
View Details MBS6495245-02 5x 0.2 mL
PKC iota, NT (Protein Kinase C iota Type, Atypical Protein Kinase C-lambda/iota, PRKC-lambda/iota, aPKC-lambda/iota, nPKC-iota, PRKCI, DXS1179E) (PE)
Ask
View Details 245169-ML650 100 µL
CYP51A1 (Cytochrome P450, Family 51, Subfamily A, Polypeptide 1, CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1) (MaxLight 650)
Ask
View Details 
C2548-39G 100 µg
CD137 (4-1BB, 4-1BB Ligand Receptor, CD137 Antigen, CDw137, ILA, T cell Antigen 4-1BB Homolog, T cell Antigen ILA, Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9)
Ask
View Details