Liproxstatin-1

Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].

Product Specifications

CAS Number

[950455-15-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Liproxstatin-1.html

Purity

99.70

Solubility

DMSO : ≥ 31 mg/mL

Smiles

ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1

Molecular Formula

C19H21ClN4

Molecular Weight

340.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16 (12) :1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3 (3) :232-243