Liproxstatin-1
Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].
Product Specifications
CAS Number
[950455-15-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Liproxstatin-1.html
Purity
99.70
Solubility
DMSO : ≥ 31 mg/mL
Smiles
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
Molecular Formula
C19H21ClN4
Molecular Weight
340.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16 (12) :1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3 (3) :232-243
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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