8-Hydroxy-2'-deoxyguanosine-15N5

8-Hydroxy-2'-deoxyguanosine-15N5 is the 15N labeled 8-Hydroxy-2'-deoxyguanosine[1]. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis[2].

Product Specifications

CAS Number

[569649-11-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-hydroxy-2-deoxyguanosine-15n5.html

Concentration

86.81 μM * 1.2 mL in Water

Purity

99.5

Solubility

10 mM in DMSO

Smiles

O=C1[15N]([C@]2([H])O[C@@H]([C@H](C2)O)CO)C3=C(C([15N]=C([15NH]3)[15NH2])=O)[15NH]1

Molecular Formula

C10H13 15N5O5

Molecular Weight

288.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG) : A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27 (2) :120-39.