Human AGRP Protein (Highly Pure)

<strong>Human AGRP Protein (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2011543_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 250 µg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20℃_x000D_ <strong>Keywords:</strong> AGRP protein (His tag), Recombinant Human AGRP protein (His tag), Agouti-related protein, AGRT protein, ART protein, ASIP2 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Andermann ML, Lowell BB. Toward a Wiring Diagram Understanding of Appetite Control Neuron. 2017 Aug 16;95(4):757-778._x000D_ 2: Koerperich ZM, Ericson MD, Freeman KT, Speth RC, Pogozheva ID, Mosberg HI, Haskell-Luevano C. Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists J Med Chem. 2020 Mar 12;63(5):2194-2208._x000D_ 3: Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C. Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R ACS Chem Neurosci. 2021 Feb 3;12(3):542-556._x000D_ 4: Sohn JW. Network of hypothalamic neurons that control appetite BMB Rep. 2015 Apr;48(4):229-33._x000D_ 5: Konturek SJ, Konturek JW, Pawlik T, Brzozowski T. Brain-gut axis and its role in the control of food intake J Physiol Pharmacol. 2004 Mar;55(1 Pt 2):137-54._x000D_ 6: Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view Nat Metab. 2021 Mar;3(3):299-308._x000D_ 7: Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types Nat Neurosci. 2017 Mar;20(3):484-496._x000D_ 8: Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity Hypertension. 2020 Aug;76(2):589-597._x000D_ 9: Yun JH, Kim K, Jung Y, Park JH, Cho HS, Lee W. Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor Biochem Biophys Res Commun. 2015 Jan 2;456(1):116-21._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33767348">10: Xia G, Han Y, Meng F, He Y, Srisai D, Farias M, Dang M, Palmiter RD, Xu Y, Wu Q. Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit Mol Psychiatry. 2021 Jul;26(7):2837-2853. </a>_x000D_ _x000D_ <strong>Products Related to Human AGRP Protein (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>