SB-366791

SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM) . SB-366791 can be used for the research of inflammation[1][2].

Product Specifications

CAS Number

[472981-92-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SB-366791.html

Purity

98.11

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC=CC(OC)=C1)/C=C/C2=CC=C(Cl)C=C2

Molecular Formula

C16H14ClNO2

Molecular Weight

287.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Lappin SC, et al. TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol. 2006;540 (1-3) :73-81.|[2] Gunthorpe MJ, et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist [published correction appears in Neuropharmacology. 2004 May;46 (6) :905]. Neuropharmacology. 2004;46 (1) :133-149.