D4R antagonist-2
D4R antagonist-2 (compound 33) is a D4R antagonist. D4R antagonist-2 has a IC50 value of 210 nM, and a Ki value of 59 nM for D4R. D4R antagonist-2 can be used in the Parkinson's disease research[1].
Product Specifications
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d4r-antagonist-2.html
Smiles
O=C(N1CC2(CCN(CC3=CNC4=C3C=CC(F)=C4)CC2)C1)C5=CC=CC=C5C
Molecular Formula
C24H26FN3O
Molecular Weight
391.48
References & Citations
[1]Jones CAH, et al. Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists. ACS Chem Neurosci. 2024 Jun 19;15 (12) :2396-2407.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor
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