D4R antagonist-2

D4R antagonist-2 (compound 33) is a D4R antagonist. D4R antagonist-2 has a IC50 value of 210 nM, and a Ki value of 59 nM for D4R. D4R antagonist-2 can be used in the Parkinson's disease research[1].

Product Specifications

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d4r-antagonist-2.html

Smiles

O=C(N1CC2(CCN(CC3=CNC4=C3C=CC(F)=C4)CC2)C1)C5=CC=CC=C5C

Molecular Formula

C24H26FN3O

Molecular Weight

391.48

References & Citations

[1]Jones CAH, et al. Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists. ACS Chem Neurosci. 2024 Jun 19;15 (12) :2396-2407.