Loteprednol Etabonate

Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].

Product Specifications

CAS Number

[82034-46-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Loteprednol-Etabonate.html

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(OC(OCC)=O)C(OCCl)=O)=C1

Molecular Formula

C24H31ClO7

Molecular Weight

466.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10 (4) :329-39.|[2]Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc) . 2000 May;36 (5) :313-20.|[3]Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55 (3) :178-83.|[4]Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92 (4) :455-9.|[5]Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623.