(Rac) -XL177A

(Rac) -XL177A is the racemic isomer of XL177A (HY-138794) . XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell-killing effects through a p53-dependent mechanism[1].

Product Specifications

CAS Number

[2417089-73-5]

UNSPSC

12352005

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-xl177a.html

Purity

98.50

Smiles

O=C(C(C=CC1=C2Cl)=CC1=NC3=C2CCCC3)NCCCC(CC4=CC=CC=C4)C(N5CCC(CN6C=NC7=C(C=CC(NC(CCN8CCN(C)CC8)=O)=C7)C6=O)(O)CC5)=O

Molecular Formula

C48H57ClN8O5

Molecular Weight

861.47

References & Citations

[1]Schauer N J, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism[J]. Scientific reports, 2020, 10 (1) : 5324.