(Rac) -XL177A
(Rac) -XL177A is the racemic isomer of XL177A (HY-138794) . XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell-killing effects through a p53-dependent mechanism[1].
Product Specifications
CAS Number
[2417089-73-5]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-xl177a.html
Purity
98.50
Smiles
O=C(C(C=CC1=C2Cl)=CC1=NC3=C2CCCC3)NCCCC(CC4=CC=CC=C4)C(N5CCC(CN6C=NC7=C(C=CC(NC(CCN8CCN(C)CC8)=O)=C7)C6=O)(O)CC5)=O
Molecular Formula
C48H57ClN8O5
Molecular Weight
861.47
References & Citations
[1]Schauer N J, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism[J]. Scientific reports, 2020, 10 (1) : 5324.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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