Lucanthone (hydrochloride)
Product Specifications
UNSPSC Description
Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
Target Antigen
Autophagy; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lucanthone-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C(C)=CC=C2NCCN(CC)CC)SC3=C1C=CC=C3.Cl
Molecular Weight
376.94
References & Citations
[1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B2098A/Lucanthone-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B2098A/
Clinical Information
Phase 2
CAS Number
548-57-2
Curated Selection
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