Lucanthone (hydrochloride)

Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .

Product Specifications

CAS Number

[548-57-2]

UNSPSC

12352005

Target

Autophagy; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lucanthone-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(C)=CC=C2NCCN(CC)CC)SC3=C1C=CC=C3.Cl

Molecular Formula

C20H25ClN2OS

Molecular Weight

376.94

References & Citations

[1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11 (1) :109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286 (8) :6602-13.