Pantethine

Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration[1][2][3][4][5][6].

Product Specifications

CAS Number

[16816-67-4]

Product Name Alternative

D-Pantethine; LBF disulfide

UNSPSC

12352211

Hazard Statement

H400

Target

Endogenous Metabolite; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Pantethine.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(NCCSSCCNC(CCNC([C@H](O)C(C)(C)CO)=O)=O)CCNC([C@H](O)C(C)(C)CO)=O

Molecular Formula

C22H42N4O8S2

Molecular Weight

554.72

Precautions

H400

References & Citations

[1]Bocos C, et al. Pantethine stimulates lipolysis in adipose tissue and inhibits cholesterol and fatty acid synthesis in liver and intestinal mucosa in the normolipidemic rat. Environ Toxicol Pharmacol. 1998 Aug 4;6 (1) :59-66.|[2]Abou-Hamdan M, et al. Potential antiviral effects of pantethine against SARS-CoV-2. Sci Rep. 2023 Feb 8;13 (1) :2237. |[3]Penet MF, et al. Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism. Front Oncol. 2016 Nov 16;6:244. |[4]Tóth F, et al. Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid. Int J Mol Sci. 2021 Jan 2;22 (1) :403.|[5]Kavian N, et al. Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding. Arthritis Rheumatol. 2015 Jul;67 (7) :1881-90.|[6]Brunetti D, et al. Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model. Brain. 2014 Jan;137 (Pt 1) :57-68.