Lupanine (hydrochloride)

Lupanine (D-Lupanine) hydrochloride is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine hydrochloride shows binding affinity for nicotinic receptor with a Ki value of 500 nM[1].

Product Specifications

CAS Number

[1025-39-4]

Product Name Alternative

D-Lupanine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lupanine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@]([C@](C3)([H])CN(CCCC4)[C@]4([H])[C@]3([H])C2)([H])CCC1.Cl

Molecular Formula

C15H25ClN2O

Molecular Weight

284.82

Precautions

P264-P270-P330-P501

References & Citations

[1]K Yovo, et al. Comparative pharmacological study of sparteine and its ketonic derivative lupanine from seeds of Lupinus albus. Planta Med. 1984 Oct;50 (5) :420-4|[2]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.