Pexiganan

Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].

Product Specifications

CAS Number

[147664-63-9]

Product Name Alternative

MSI 78 (free base)

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pexiganan.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC(CNC([C@H]([C@@H](C)CC)NC(CN)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C122H210N32O22

Molecular Weight

2477.17

References & Citations

[1]Lamb HM, et al. Pexiganan acetate. Drugs. 1998 Dec;56 (6) :1047-52; discussion 1053-4. |[2]Ge Y, et al. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43 (4) :782-8. |[3]Zhang XL, et al. The synthetic antimicrobial peptide pexiganan and its nanoparticles (PNPs) exhibit the anti-helicobacter pylori activity in vitro and in vivo. Molecules. 2015 Mar 2;20 (3) :3972-85. |[4]Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005 Feb;26 (2) :207-16.