Inuviscolide

Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G2/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities[1][2][3].

Product Specifications

CAS Number

[63109-30-8]

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/inuviscolide.html

Solubility

10 mM in DMSO

Smiles

C[C@@]1([C@@]2([H])[C@@](CC1)([H])C(C[C@@]3([H])[C@](C(C(O3)=O)=C)([H])C2)=C)O

Molecular Formula

C15H20O3

Molecular Weight

248.32

References & Citations

[1]Máñez S, et, al. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa. Fitoterapia. 2007 Jun;78 (4) :329-31. |[2]Rozenblat S, et, al. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines. Biochem Pharmacol. 2008 Jan 15;75 (2) :369-82. |[3]Hernández V, et, al. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med. 2001 Nov;67 (8) :726-31.