VGSCs-IN-1

VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research[1].

Product Specifications

CAS Number

[1204296-79-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vgscs-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)OC1=CC2=C(C=C1)N=C(N3CCNCC3)S2

Molecular Formula

C12H12F3N3OS

Molecular Weight

303.30

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Farinato A, et al. Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels. ACS Med Chem Lett. 2023 Jun 23;14 (7) :999-1008.