(−) -L-threo-PDMP (hydrochloride)
(−) -L-threo-PDMP hydrochloride is the hydrochloride form of (−) -L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells[1][2].
Product Specifications
CAS Number
161491-04-9
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threo-pdmp-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCC(N[C@@H](CN1CCOCC1)[C@H](C2=CC=CC=C2)O)=O.Cl
Molecular Formula
C23H39ClN2O3
Molecular Weight
427.02
References & Citations
[1]Mitchell SA, et al. Glycosyltransferase Inhibitors: Synthesis of D-threo-PDMP, L-threo-PDMP, and Other Brain Glucosylceramide Synthase Inhibitors from D-or L-Serine. The Journal of Organic Chemistry. 1998, 63 (24) : 8837-8842.|[2]Chatterjee S, et al. Studies of the action of ceramide-like substances (D- and L-PDMP) on sphingolipid glycosyltransferases and purified lactosylceramide synthase. Glycoconj J. 1996 Jun;13 (3) :481-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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