Eudebeiolide B

Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research[1].

Product Specifications

CAS Number

1934299-51-0

Product Name Alternative

Plebeiolide D

UNSPSC

12352005

Target

Akt; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; Phosphatase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/eudebeiolide-b.html

Solubility

10 mM in DMSO

Smiles

O[C@]12C(C[C@@]3([H])[C@](C1)(C=CC([C@@H]3C)=O)C)=C(C(O2)=O)C

Molecular Formula

C15H18O4

Molecular Weight

262.30

References & Citations

[1]Kim MH, et.al. Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling. Pharmaceuticals (Basel) . 2020 Dec 16;13 (12) :468.