Cortistatin-14
Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5) . Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3].
Product Specifications
CAS Number
186901-48-4
UNSPSC
12352209
Target
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/cortistatin-14.html
Purity
99.98
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@@H]6CCCN6)=O)CSSC[C@@H](C(N[C@@H](CCCCN)C(N)=O)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC7=CC=CC=C7)NC([C@]([H])([C@@H](C)O)NC([C@H](CCCCN)NC1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C81H114N20O18S2
Molecular Weight
1720.03
References & Citations
[1]Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60 (1) :151-6.|[2]Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803 (1-2) :54-60.|[3]Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46 (1) :40-50.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
SSTR1; SSTR2; SSTR3; SSTR4; SSTR5
Available Sizes
Frequently Asked Questions
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