4-Hydroxychalcone

4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

Product Specifications

CAS Number

[20426-12-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxychalcone-1.html

Purity

99.29

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C15H12O2

Molecular Weight

224.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.