1,3-Butanediol

1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB) . 1,3-Butanediol has cerebral protective and hypoglycaemic effect[1][2][3].

Product Specifications

CAS Number

[107-88-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/1-3-butanediol.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 500 mg/mL

Smiles

CC(O)CCO

Molecular Formula

C4H10O2

Molecular Weight

90.12

Precautions

H302, H315, H319, H335

References & Citations

[2]R B Tobin, et al. Nutritional and metabolic studies in humans with 1,3-butanediol. Fed Proc. 1975 Nov;34 (12) :2171-6.|[3]McCarthy CG, et al. Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol. J Pharmacol Exp Ther. 2021 Nov;379 (3) :245-252.|[4]McCarthy CG, et al. Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322 (3) :H466-H473. |[5]Gueldry S, et al. Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats. Stroke. 1990 Oct;21 (10) :1458-63.|[1]C Marie, et al. Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study. J Cereb Blood Flow Metab. 1987 Dec;7 (6) :794-800.