L 659286
L 659286 is an inhibitor of human polymorphonuclear leukocyte elastase (PMN elastase) (Ki=0.4 μM) . Intratracheal injection of L 659286 can induce lung injury in hamsters.
Product Specifications
CAS Number
119742-06-2
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-659286.html
Smiles
O=C(C(N1C2=O)=C(CS([C@@]1([C@H]2OC)[H])(=O)=O)CSC(N(NC3=O)C)=NC3=O)N4CCCC4
Molecular Formula
C17H21N5O7S2
Molecular Weight
471.51
References & Citations
[1]Pharmacological profile of the substituted beta‐lactam L‐659,286: A member of a new class of human PMN elastase inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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