PP 3

PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1].

Product Specifications

CAS Number

[5334-30-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pp-3.html

Purity

98.78

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=C2C(N(C3=CC=CC=C3)N=C2)=NC=N1

Molecular Formula

C11H9N5

Molecular Weight

211.23

Precautions

H315, H319

References & Citations

[1]Traxler P, et al. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4- (phenylamino) pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40 (22) :3601-16.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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