CypK

CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates[1][2].

Product Specifications

CAS Number

[1610703-09-7]

Product Name Alternative

N-Cyclopropene-L-Lysine

UNSPSC

12352211

Target

Amino Acid Derivatives

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cypk.html

Purity

98.30

Smiles

N[C@@H](CCCCNC(OCC1C(C)=C1)=O)C(O)=O

Molecular Formula

C12H20N2O4

Molecular Weight

256.30

References & Citations

[1]Oller-Salvia B. Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction. J Vis Exp. 2018 Sep 14; (139) :58066.|[2]Oller-Salvia B, et, al. Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction. Angew Chem Int Ed Engl. 2018 Mar 5;57 (11) :2831-2834.