Arenobufagin

Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway[1][2].

Product Specifications

CAS Number

[464-74-4]

UNSPSC

12352005

Target

Akt; Apoptosis; Atg8/LC3; Autophagy; Caspase; mTOR; PARP; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Arenobufagin.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic)

Smiles

C[C@]([C@@H](C(C=C1)=COC1=O)CC2)(C3=O)[C@]2([C@@](CC[C@@]4([H])[C@@]5(CC[C@H](O)C4)C)([H])[C@]5([H])[C@@H]3O)O

Molecular Formula

C24H32O6

Molecular Weight

416.51

References & Citations

[1]Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34 (6) :1331-42.|[2]Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83 (9) :1251-60.|[3]Cruz Jdos S, et al. Arenobufagin, a compound in toad venom, blocks Na (+) -K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239 (1-3) :223-6.