SB-209247

SB-209247 is a selective, high affinity and orally active leukotriene B4 (LTB4) receptor antagonist with a Ki of 0.78 nM. SB-209247 blocks LTB4-induced Ca2+ mobilization with an IC50 of 6.6 nM. SB-209247 shows a potent anti-inflammatory activity[1].

Product Specifications

CAS Number

[154413-61-3]

UNSPSC

12352005

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-209247.html

Purity

99.33

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C/C1=NC(CSC2=C(Cl)C=CC=C2Cl)=CC=C1OCCC3=CC=CC=C3

Molecular Formula

C23H19Cl2NO3S

Molecular Weight

460.37

References & Citations

[1]R A Daines, et al. (E) -3-[6-[[ (2,6-dichlorophenyl) thio]methyl]-3- (2-phenylethoxy) -2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity. J Med Chem. 1996 Sep 13;39 (19) :3837-41.