Lipid A Salmonella (Highly Pure)

<strong>Lipid A (Salmonella, Highly Pure)</strong>_x000D_ <b>Catalog number: </b>MDP0894_x000D_ <b>Name:</b> 2-Deoxy-6-O-{2-Deoxy-2-[(R)-3-(Dodecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-(Tetradecanoyloxy)Tetradecanoyl]-beta-D-Glucopyranosyl}-2-[(R)-3-(Hexadecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-Hydroxytetradecanoyl]-alpha-D-Glucopyranose 1,4'-Diphosphate_x000D_ <b>Other name(s): </b>Lipid A (Salmonella)_x000D_ <b>Molecular Formula: </b>C₁₁₀H₂₀₈N₂O₂₆P₂_x000D_ <b>Molecular Mass: </b>2036.8_x000D_ <b>CAS #: </b>100742-61-8_x000D_ <b>Storage Temperature: </b>-20C_x000D_ _x000D_ <b>Indication for Use:</b>_x000D_ This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use._x000D_ _x000D_ <b>Safety:</b>_x000D_ User must review the Safety Data Sheet (SDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes._x000D_ _x000D_ <b>References:_x000D_ </b>_x000D_ _x000D_ 1: Gao J, Guo Z. Progress in the synthesis and biological evaluation of lipid A_x000D_ and its derivatives. Med Res Rev. 2018 Mar;38(2):556-601._x000D_ _x000D_ 2: Wang X, Quinn PJ, Yan A. Kdo2 -lipid A: structural diversity and impact on_x000D_ immunopharmacology. Biol Rev Camb Philos Soc. 2015 May;90(2):408-27._x000D_ _x000D_ 3: Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D'Errico G,_x000D_ Zamyatina A, Peri F, Berisio R, Jerala R, Jim√©nez-Barbero J, Silipo A, Mart√≠n-_x000D_ Santamar√≠a S. Chemistry of lipid A: at the heart of innate immunity. Chemistry._x000D_ 2015 Jan 7;21(2):500-19. doi: 10.1002/chem.201403923. Epub 2014 Oct 29. PMID:_x000D_ 25353096._x000D_ _x000D_ 4: Verpalen ECJM, Brouwer AJ, Boons GJ. Synthesis of monophosphoryl lipid A_x000D_ using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr Res. 2020_x000D_ Dec;498:108152._x000D_ _x000D_ 5: Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity_x000D_ relationships of the lipid a family of glycolipids. Curr Opin Chem Biol. 2017_x000D_ Oct;40:127-137._x000D_ _x000D_ 6: Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Lipid A structural modifications_x000D_ in extreme conditions and identification of unique modifying enzymes to define_x000D_ the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta_x000D_ Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450._x000D_ _x000D_ 7: Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is_x000D_ anticorrelated with lipid a leaflet affinity. PLoS One. 2020 Nov_x000D_ 30;15(11):e0242907._x000D_ _x000D_ 8: Fujimoto Y, Adachi Y, Akamatsu M, Fukase Y, Kataoka M, Suda Y, Fukase K,_x000D_ Kusumoto S. Synthesis of lipid A and its analogues for investigation of the_x000D_ structural basis for their bioactivity. J Endotoxin Res. 2005;11(6):341-7._x000D_ _x000D_ 9: Di Lorenzo F, Crisafi F, La Cono V, Yakimov MM, Molinaro A, Silipo A. The_x000D_ Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from_x000D_ Antarctic Environments. Mar Drugs. 2020 Nov 26;18(12):592._x000D_ _x000D_ 10: Cheng R, Fontana F, Xiao J, Liu Z, Figueiredo P, Shahbazi MA, Wang S, Jin J,_x000D_ Torrieri G, Hirvonen JT, Zhang H, Chen T, Cui W, Lu Y, Santos HA. Recombination_x000D_ Monophosphoryl Lipid_A-Derived Vacosome for the Development of Preventive Cancer_x000D_ Vaccines. <a href="https://pubmed.ncbi.nlm.nih.gov/32960566/">ACS Appl Mater Interfaces</a>. 2020 Oct 7;12(40):44554-44562._x000D_ _x000D_ Products Related to Lipid A (Salmonella): <a href="https://moleculardepot.com/product-category/peptides/">Peptides</a>