MG-101
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer[1].
Product Specifications
CAS Number
[110044-82-1]
Product Name Alternative
Calpain inhibitor I; Ac-LLnL-CHO; ALLN
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MG-101.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C
Molecular Formula
C20H37N3O4
Molecular Weight
383.53
Precautions
H315, H319, H335
References & Citations
[1]Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437 (2) :325-330.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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