Umbelliferone-d5

Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573) . Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats[1][2].

Product Specifications

CAS Number

[1215373-23-1]

Product Name Alternative

7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Fluorescent Dye; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Purity

98.0

Solubility

10 mM in DMSO|DMSO : ≥ 14.29mg/mL|H2O : 0.1mg/mL (ultrasonic)

Smiles

OC1=C([2H])C([2H])=C(C([2H])=C([2H])C(O2)=O)C2=C1[2H]

Molecular Formula

C9HD5O3

Molecular Weight

167.17

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Yu SM, et al. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12 (3) :3869-3873.