WIN 51708

WIN 51708 is a nonpeptide antagonist of neurokinin (NK) -1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor[1].

Product Specifications

CAS Number

[144177-30-0]

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/win-51708.html

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC4=NC5=NC6=CC=CC=C6N5C=C4C2)([H])[C@@]7([H])[C@](CC3)([C@@](O)(CC7)C#C)C

Molecular Formula

C29H33N3O

Molecular Weight

439.59

References & Citations

[1]Sachais BS, et al. Both extracellular and transmembrane residues contribute to the species selectivity of the neurokinin-1 receptor antagonist WIN 51708. Mol Pharmacol. 1994 Jul;46 (1) :122-8.