Guggulsterone
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-) - (E) -Guggulsterone (HY-N7781) and (Z) -Guggulsterone (HY-110066), respectively[3].
Product Specifications
CAS Number
[95975-55-6]
Product Name Alternative
Z/E-Guggulsterone
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Akt; Apoptosis; Autophagy; Caspase; FXR; JNK
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/guggulsterone.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Formula
C21H28O2
Molecular Weight
312.45
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107738/Guggulsterone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107738/Guggulsterone-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase; JNK
Available Sizes
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