PERK-IN-5
PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively) . PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model[1].
Product Specifications
CAS Number
2616821-91-9
UNSPSC
12352005
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/perk-in-5.html
Concentration
10mM
Purity
99.40
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CCC1=C(C2=CN=C(N)C(C(NC(C)C)=O)=C2)C=CC(NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=C1
Molecular Formula
C25H26F2N4O3
Molecular Weight
468.50
References & Citations
[1]Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP710104 20 µg
Eph receptor A3 (EPHA3) (NM_005233) Human Recombinant Protein
Sign In for Pricing
View Details ![Phosphoribosyl pyrophosphate amidotransferase (PPAT) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3C6]](https://cdn.genprice.uk/products/937/6868c34f994c49e6dc3f4576/imageurl/ta504457am.webp)
TA504457AM 100 µL
Phosphoribosyl pyrophosphate amidotransferase (PPAT) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3C6]
Sign In for Pricing
View Details 
