RJR-2429
RJR-2429 is a nAChR agonist (EC50: 59 nM) . RJR-2429 binds with high affinity to α4β2 receptor subtype (Ki = 1 nM) . RJR-2429 induces ileum contraction[1].
Product Specifications
CAS Number
91556-75-1
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rjr-2429.html
Smiles
N1(CC2)C(C3=CC=CN=C3)CC2CC1
Molecular Formula
C12H16N2
Molecular Weight
188.27
References & Citations
[1]Bencherif M, et al. The heterocyclic substituted pyridine derivative (+/-) -2- (-3-pyridinyl) -1-azabicyclo[2.2.2]octane (RJR-2429) : a selective ligand at nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 1998 Mar;284 (3) :886-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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