LCH-7749944
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
Product Specifications
CAS Number
796888-12-5
Product Name Alternative
GNF-PF-2356
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; PAK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lch-7749944.html
Purity
99.68
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC(NC2=NC(NCC3OCCC3)=C4C=CC=CC4=N2)=CC=C1
Molecular Formula
C20H22N4O2
Molecular Weight
350.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317 (1) :24-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK4
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY423333 100 µg
RUNDC2B (NM_001012391) Human Over-expression Lysate
Sign In for Pricing
View Details 
