LCH-7749944
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
Product Specifications
CAS Number
796888-12-5
Product Name Alternative
GNF-PF-2356
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; PAK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lch-7749944.html
Purity
99.68
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC(NC2=NC(NCC3OCCC3)=C4C=CC=CC4=N2)=CC=C1
Molecular Formula
C20H22N4O2
Molecular Weight
350.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317 (1) :24-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK4
Available Sizes
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