Lys-psi (CH2NH) -Trp (Nps) -OMe
Lys-psi (CH2NH) -Trp (Nps) -OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp (Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi (CH2NH) -Trp (Nps) -OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi (CH2NH) -Trp (Nps) -OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.
Product Specifications
CAS Number
141365-20-0
Product Name Alternative
LTNAM
UNSPSC
12352005
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lys-psi-ch2nh-trp-nps-ome.html
Smiles
O=C(OC)[C@@H](NC[C@@H](N)CCCCN)CC1=C(SC2=CC=CC=C2[N+]([O-])=O)NC3=C1C=CC=C3
Molecular Formula
C24H31N5O4S
Molecular Weight
485.60
References & Citations
[1]Prolonged antinociceptive activity of pseudodipeptide analogues of Lys-Trp (Nps) and Trp (Nps) -Lys
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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