Anti-Glial Fibrillary Acidic Protein (GFAP) Antibody

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Immunoblotting: use at 1-5ug/mL. A band of ~50kDa is detected. <br><br>Immunofluorescence: use at 10ug/mL. <br><br>These are recommended concentrations. <br><br>Endusers should determine optimal concentrations for their application.

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is expressed by numerous cell types of the central nervous system. It is involved in many important CNS processes, including cell communication and the functioning of the blood brain barrier. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell's cytoskeleton. GFAP is thought to help to maintain astrocyte strength and shape. There are multiple disorders associated with improper GFAP regulation. GFAP levels are used as a marker of neurologic damage in adults who suffer strokes and traumatic brain injuries.