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Deoxynivalenol (Standard)

Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors[1].

Product Specifications

CAS Number

51481-10-8

Product Name Alternative

Vomitoxin (Standard)

UNSPSC

12352005

Target

P-glycoprotein; Reference Standards

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/deoxynivalenol-standard.html

Smiles

O=C(C(C)=C1)[C@@H](O)[C@@]2(CO)[C@]1([H])O[C@]3([H])[C@H](O)C[C@@]2(C)[C@@]34OC4

Molecular Formula

C15H20O6

Molecular Weight

296.32

References & Citations

[1]Sergent T, et al. Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellularmetabolism at realistic intestinal concentrations. Toxicol Lett. 2006 Jul 1;164 (2) :167-76.|[2]Diesing AK, et al. Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2. Toxicol Lett. 2011 Jan 15;200 (1-2) :8-18. |[3]Collins TF, et al. Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats. Food Chem Toxicol. 2006 Jun;44 (6) :747-57.|[4]Pestka JJ, et al. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol Lett. 2008 May 5;178 (2) :83-7.|[5]Forsell JH, et al. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. Food Chem Toxicol. 1987 Feb;25 (2) :155-62.|[6]Sergent T, et al. Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellularmetabolism at realistic intestinal concentrations. Toxicol Lett. 2006 Jul 1;164 (2) :167-76.|[7]Diesing AK, et al. Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2. Toxicol Lett. 2011 Jan 15;200 (1-2) :8-18. |[8]Collins TF, et al. Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats. Food Chem Toxicol. 2006 Jun;44 (6) :747-57.|[9]Pestka JJ, et al. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol Lett. 2008 May 5;178 (2) :83-7.|[10]Forsell JH, et al. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. Food Chem Toxicol. 1987 Feb;25 (2) :155-62.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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