APC Rabbit Monoclonal Antibody (APC)
APC Rabbit Monoclonal Antibody (APC)
Product Specifications
Product Name Alternative
Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3; APRF
UniProt
P25054
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human APC Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF) -induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Target
Adenomatous polyposis coli protein
Clonality
Monoclonal
Clone
BHCFX3
Conjugation
Unconjugated
Field of Research
Cancer Biology, Cardiovascular Research, Cell Biology, Disease Biomarkers, Epigenetics & Chromatin, Neuroscience, Stem Cell & Developmental Biology
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Dilution
WB 1:500-2000 IHC 1:50-200 ICC/IF 1:50-200 IP 1:20
Form
Liquid
Molecular Weight
160 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IF, IHC, IP, WB
Host or Source
Rabbit
Preservative
Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.
Isotype
Rabbit IgG
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