Maleimide-PEG8-Val-Ala-PAB
Maleimide-PEG8-Val-Ala-PAB is an ADC linker composed of the cleavable Val-Ala-PAB (HY-125933) linker and the probe molecule Maleimide (HY-W007324) . Maleimide-PEG8-Val-Ala-PAB can be used to connect Cetuximab (HY-P9905) monoclonal antibody and CDK inhibitor SNS-032 (HY-10008) to synthesize antibody-drug conjugates (ADCs) [1].
Product Specifications
UNSPSC
12352005
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maleimide-peg8-val-ala-pab.html
Smiles
O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](C)C(NC1=CC=C(CO)C=C1)=O)=O)C(C)C)=O)CCN2C(C=CC2=O)=O
Molecular Formula
C41H65N5O15
Molecular Weight
867.98
References & Citations
[1]Cheung A, Chenoweth A M, Johansson A, et al. Anti-EGFR antibody-drug conjugate carrying an inhibitor targeting CDK restricts triple-negative breast cancer growth[J]. Clinical Cancer Research, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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