Maleimide-PEG8-Val-Ala-PAB

Maleimide-PEG8-Val-Ala-PAB is an ADC linker composed of the cleavable Val-Ala-PAB (HY-125933) linker and the probe molecule Maleimide (HY-W007324) . Maleimide-PEG8-Val-Ala-PAB can be used to connect Cetuximab (HY-P9905) monoclonal antibody and CDK inhibitor SNS-032 (HY-10008) to synthesize antibody-drug conjugates (ADCs) [1].

Product Specifications

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/maleimide-peg8-val-ala-pab.html

Smiles

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](C)C(NC1=CC=C(CO)C=C1)=O)=O)C(C)C)=O)CCN2C(C=CC2=O)=O

Molecular Formula

C41H65N5O15

Molecular Weight

867.98

References & Citations

[1]Cheung A, Chenoweth A M, Johansson A, et al. Anti-EGFR antibody-drug conjugate carrying an inhibitor targeting CDK restricts triple-negative breast cancer growth[J]. Clinical Cancer Research, 2024.