PKCTheta-IN-1
PKCTheta-IN-1 (Compound 19) is a selective macrocyclic PKCTheta inhibitor with IC50 value of 0.1 nM[1].
Product Specifications
CAS Number
2948289-20-9
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pkctheta-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=NC(N(CC[C@@H](C)O3)C(C)(C)NC4=O)=C4C=C2)C5=C3C=CN=C5N1
Molecular Formula
C19H20N6O3
Molecular Weight
380.40
References & Citations
[1] Crosignani S, et al. Discovery of a novel series of selective macrocyclic PKCTheta inhibitors. Bioorg Med Chem Lett. 2024 Mar 1;100:129630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCθ
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