Proscillaridin A
Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1].
Product Specifications
CAS Number
466-06-8
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/proscillaridin-a.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@]([C@@]1(CC2)C)(CC[C@@H]1C(C=C3)=COC3=O)[C@@](CCC4=C[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)CC6)([H])[C@@]2([H])[C@]46C
Molecular Formula
C30H42O8
Molecular Weight
530.65
Precautions
H301
References & Citations
[1]Bielawski K, et al. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.Biol Pharm Bull. 2006 Jul;29 (7) :1493-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I; Topo II
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
44080126 3x 1.0µg DNA
SLC27A6 CRISPRa sgRNA lentivector (set of three targets)(Rat)
Sign In for Pricing
View Details 
22928064 1.0 µg DNA
H2-Oa Lentiviral Vector (Mouse) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details GTR15137703 1 Vial
Lentiviral human ATP8B2 shRNA (UAS) - Lentiviral human ATP8B2 shRNA (UAS, iRFP) (100)
Sign In for Pricing
View Details 
045419 50 µg
CSN2, Recombinant, Human, aa16-226, His-Tag (COP9 Signalosome Complex Subunit 2, ALIEN, COP9 Constitutive Photomorphogenic Homolog Subunit 2, COPS2, JAB1-containing Signalosome Subunit 2, Signalosome Subunit 2, SGN2, Thyroid Receptor-interacting Protein 15, TR-interacting Protein 15, TRIP 15, TRIP15, TRIP-15)
Sign In for Pricing
View Details