AT1R antagonist 3
AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM) . AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models[1].
Product Specifications
CAS Number
3053482-15-5
UNSPSC
12352005
Target
Angiotensin Receptor; Calcium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/at1r-antagonist-3.html
Smiles
O=C(C1=CC2=C(NC(SCC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=N2)C=C1)O
Molecular Formula
C22H16N6O2S
Molecular Weight
428.47
References & Citations
[1]Gutiérrez-Hernández A, et al., Synthesis, biosimulation and pharmacological evaluation of benzimidazole derivatives with antihypertensive multitarget effect. Bioorg Med Chem Lett. 2024 Jul 6;110:129879.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Frequently Asked Questions
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