Human Aurora Kinase B Protein

<strong>Human Aurora Kinase B Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011818_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> STK5 protein, STK1 protein, aurkb-sv1 protein, ARK2 protein, AIK2 protein, Aurora kinase B protein, Aurora 1 protein, AIM1 protein, aurkb-sv2 protein, , AURKB protein, STK12 protein, Serine/threonine protein kinase 12 protein, AIM1 protein, Aurora and Ipl_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, Xie Y, Ishizawa K, Osmanbeyoglu HU, Lyu Y, Roper N, Guha U, Rudin CM, Kris MG, Hsieh JJ, Cheng EH. Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis Cancer Cell. 2021 Sep 13;39(9):1245-1261.e6._x000D_ 2: Borah NA, Reddy MM. Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer Molecules. 2021 Apr 1;26(7):1981._x000D_ 3: Jiang J, Wang J, Yue M, Cai X, Wang T, Wu C, Su H, Wang Y, Han M, Zhang Y, Zhu X, Jiang P, Li P, Sun Y, Xiao W, Feng H, Qing G, Liu H. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis Cancer Cell. 2020 Feb 10;37(2):200-215.e5._x000D_ 4: Joshi SK, Nechiporuk T, Bottomly D, Piehowski PD, Reisz JA, Pittsenbarger J, Kaempf A, Gosline SJC, Wang YT, Hansen JR, Gritsenko MA, Hutchinson C, Weitz KK, Moon J, Cendali F, Fillmore TL, Tsai CF, Schepmoes AA, Shi T, Arshad OA, McDermott JE, Babur O, Watanabe-Smith K, Demir E, D'Alessandro A, Liu T, Tognon CE, Tyner JW, McWeeney SK, Rodland KD, Druker BJ, Traer E. The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance Cancer Cell. 2021 Jul 12;39(7):999-1014.e8._x000D_ 5: Xu J, Yu X, Martin TC, Bansal A, Cheung K, Lubin A, Stratikopoulos E, Cahuzac KM, Wang L, Xie L, Zhou R, Shen Y, Wu X, Yao S, Qiao R, Poulikakos PI, Chen X, Liu J, Jin J, Parsons R. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B Cancer Discov. 2021 Dec 1;11(12):3064-3089._x000D_ 6: Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG Jr. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival Cancer Discov. 2019 Feb;9(2):230-247._x000D_ 7: Li T, Huang T, Du M, Chen X, Du F, Ren J, Chen ZJ. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis Science. 2021 Mar 19;371(6535):eabc5386._x000D_ 8: Broad AJ, DeLuca KF, DeLuca JG. Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells J Cell Biol. 2020 Mar 2;219(3):e201905144._x000D_ 9: Ito S, Goto H, Kuniyasu K, Shindo M, Yamada M, Tanaka K, Toh GT, Sawa M, Inagaki M, Bartek J, Masai H. Cdc7 kinase stimulates Aurora B kinase in M-phase Sci Rep. 2019 Dec 9;9(1):18622._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33417980">10: Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, Korolev AM, Ethayathulla AS, Das U, Shchekotikhin AE, Kaur P. Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B Biochimie. 2021 Mar;182:152-165. </a>_x000D_ _x000D_ <strong>Products Related to Human Aurora Kinase B Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>