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Phospho-c-Jun (S73)+JunD (S100) Recombinant Rabbit Monoclonal Antibody [JE65-46]

Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity. Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Activator protein 1 antibody AP 1 antibody AP-1 antibody AP1 antibody cJun antibody Enhancer Binding Protein AP1 antibody Jun Activation Domain Binding Protein antibody JUN antibody Jun oncogene antibody JUN protein antibody Jun proto oncogene antibody JUN_HUMAN antibody JUNC antibody Oncogene JUN antibody p39 antibody Proto oncogene c jun antibody Proto oncogene cJun antibody Proto-oncogene c-jun antibody Transcription Factor AP 1 antibody Transcription factor AP-1 antibody Transcription Factor AP1 antibody V jun avian sarcoma virus 17 oncogene homolog antibody V jun sarcoma virus 17 oncogene homolog (avian) antibody V jun sarcoma virus 17 oncogene homolog antibody V-jun avian sarcoma virus 17 oncogene homolog antibody vJun Avian Sarcoma Virus 17 Oncogene Homolog antibody Activator protein 1 antibody AP 1 antibody AP1 antibody Jun D antibody jun D proto oncogene antibody Jund antibody JunD FL isoform antibody JUND_HUMAN antibody Transcription factor jun D antibody Transcription factor jun-D antibody

Abbreviation

Transcription factor Jun Activator protein 1 (AP1) Proto-oncogene c-Jun Transcription factor AP-1 subunit Jun V-jun avian sarcoma virus 17 oncogene homolog p39 JUN Transcription factor JunD Transcription factor AP-1 subunit JunD JUND

Swiss Prot

P05412 Human, P17535 Human, P05627 Mouse, P15066 Mouse, P17325 Rat, P52909 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic phosphopeptide corresponding to residues around Ser73 of human c-Jun.

Isotype

IgG

Clone

JE65-46

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HeLa cell lysate, HeLa treated with 25μg/mL anisomycin for 30 minutes cell lysate, NIH/3T3 cell lysate, NIH/3T3 treated with 25μg/mL anisomycin for 30 minutes cell lysate, RAW264.7 cell lysate, PC-12 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 40/45 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

Frequently Asked Questions

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