Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody - Library Pack

Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:<br><br> 15801 - Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody - Clone GC12-316.4 - Isotype IgG3<br> 15802 - Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody - Clone GC12-323.6 - Isotype IgG1<br> 15803 - Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody - Clone GC12-351.2 - Isotype IgG1<br> 15804 - Anti-Neisseria gonorrhoeae Mouse Monoclonal Antibody - Clone GC12-351.4 - Isotype IgG1<br>

Pool of UV-inactivated Neisseria gonorrhoeae cells: Neisseria Reference laboratory strains G-7, R-11, and 7122 (W-I), 5766 and 8038 (W-II), and 8660 (W-III).

These antibodies have been qualified for use in ELISA to detect N. gonorrhoeae. <br><br>End users should determine optimal concentrations for their applications.

These antibodies recognize N. gonorrhoeae. They do not cross-react with N. meningitides, N. cinerea, N. lactamica, N. sicca, B. catarrhalis, E. coli, Proteus mirabilis, Gardnerella vaginalis, Group B Strep. or Chlamydia trachomatis.

Neisseria gonorrhoeae is a gram-negative coccus and is the cause of the sexually transmitted disease gonorrhea with humans as its only natural host. Although it does not produce any exotoxins, Neisseria gonorrhoeae has a wide range of virulence determinants. The first stages of infection, which include adherence and invasion, are mediated by surface components; N. gonorrhoeae first attaches to epithelial cells by means of its fimbriae. After initial attachment, the bacteria enter a second stage of binding mediated by the outer membrane protein P.II (also known as Opa) which is needed for tight binding and invasion of epithelial cells. P.II from one bacterium will bind to lipooligosaccharide of an adjacent bacterium, which allows for the construction of a small colony that may function similarly to a biofilm. Neisseria gonorrhoeae also produces an IgA1 protease that may take part in the colonization stage.