Cot inhibitor-2

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1].

Product Specifications

CAS Number

[915363-56-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cot-inhibitor-2.html

Purity

99.65

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

Molecular Formula

C26H25Cl2FN8

Molecular Weight

539.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3485-8.