Rupintrivir-d7
Product Specifications
UNSPSC Description
Rupintrivir-d7 is a deuterated labeled Rupintrivir[1]. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect[2][3].
Target Antigen
Enterovirus; Isotope-Labeled Compounds; Virus Protease
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Others
Field of Research
Infection
Smiles
CC1=CC(C(N[C@H](C(C[C@H](C(N[C@H](/C=C/C(OCC)=O)C[C@@H]2CCNC2=O)=O)CC3=CC=C(F)C=C3)=O)C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)=NO1
Molecular Weight
605.71
References & Citations
[1]Patick AK, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50.|[2]Danov O, et al. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res. 2019 Oct 22;20(1):228.|[3]Dragovich PS, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem. 1999 Apr 8;42(7):1203-12.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Curated Selection
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