Spongosine

Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Product Specifications

CAS Number

[24723-77-1]

Product Name Alternative

2-Methoxyadenosine; 2-O-Methylisoguanosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/spongosine.html

Purity

95.43

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC1=NC(OC)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302, H315, H319

References & Citations

[1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26 (6) :1490-1500.|[2]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.