Fluorofolin

Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa[1].

Product Specifications

CAS Number

[2757070-32-7]

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fluorofolin.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=NC2=C1C(C=CN3CC4=CC=NC(F)=C4)=C3C=C2

Molecular Formula

C16H13FN6

Molecular Weight

308.31

References & Citations

[1]Connor Chain, et al. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nat Microbiol. 2024 May;9 (5) :1207-1219.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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