Fluorofolin
Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa[1].
Product Specifications
CAS Number
[2757070-32-7]
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fluorofolin.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(N)=NC2=C1C(C=CN3CC4=CC=NC(F)=C4)=C3C=C2
Molecular Formula
C16H13FN6
Molecular Weight
308.31
References & Citations
[1]Connor Chain, et al. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nat Microbiol. 2024 May;9 (5) :1207-1219.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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